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Inferring cluster-based networks from differently stimulated multiple time-course gene expression data

机译:从不同刺激的多个时程基因表达数据推断基于簇的网络

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摘要

Motivation: Clustering and gene network inference often help to predict the biological functions of gene subsets. Recently, researchers have accumulated a large amount of time-course transcriptome data collected under different treatment conditions to understand the physiological states of cells in response to extracellular stimuli and to identify drug-responsive genes. Although a variety of statistical methods for clustering and inferring gene networks from expression profiles have been proposed, most of these are not tailored to simultaneously treat expression data collected under multiple stimulation conditions.
机译:动机:聚类和基因网络推断通常有助于预测基因亚群的生物学功能。最近,研究人员积累了在不同处理条件下收集的大量时程转录组数据,以了解细胞对细胞外刺激的生理状态并鉴定药物反应性基因。尽管已经提出了多种用于从表达谱中聚类和推断基因网络的统计方法,但是这些统计方法中的大多数都不适合同时处理在多种刺激条件下收集的表达数据。

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